Scars · Pigment · Comparison

CO2 vs Pico Laser

One for scar texture, one for pigment

Fractional CO2 targets texture and scar architecture. Pico acts on pigment already in the skin. Some faces need both, in a planned order. Results vary.

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In Brief

CO2 vs pico laser is really a question of target. Fractional CO2 targets scars and texture, while pico targets discrete pigment. Faces with both may need both, staged apart. Pico does not rebuild scars, and CO2 does not cleanly remove sun spots. Results vary. Our main page on this topic is Pico Laser Singapore.

At a Glance: CO2 vs Pico Laser

What it comparesFractional CO2 laser, for scars and texture, and pico laser, for discrete pigment.
Main differenceCO2 targets scars and texture; pico targets pigment.
Both neededFaces with both problems may need both lasers, staged apart.
Who should avoid combiningActive melasma, active acne, infection, keloid tendency, a recent tan or pregnancy.
What it cannot doPico does not rebuild scars; CO2 does not cleanly remove sun spots.
Main risksPost-inflammatory hyperpigmentation, prolonged redness, and pale or mottled spots after frequent toning.

What the Research Shows: CO2 vs Pico Laser

  • A 2025 systematic review of seven studies of fractional laser for acne scars reported most patients showing roughly 30% to 70% improvement, with transient redness, swelling and post-inflammatory hyperpigmentation the most common adverse events. [1]
  • A 2024 prospective study of 12 Chinese patients given one treatment reported mean freckle clearance of 74.46%; at eight weeks, one had hyperpigmentation and one had hypopigmentation. [2]
  • A 2023 randomised trial of 60 women with melasma reported week-24 melasma severity (MASI) improvement of 35.9% with picosecond Nd:YAG, 25.5% with alexandrite and 24.0% with hydroquinone; four patients (6.8%) had recurrence. [5]
  • A 2022 randomised split-face trial, funded by Beiersdorf, of 59 patients with phototypes III to IV found no significant difference in pigmentation score between sunscreens after picosecond laser. [6]

Figures describe published study groups, which may have used other devices or protocols. They do not predict your result. Updated 6 November 2026.

About This Treatment

The short answer

These lasers do different jobs. Pigment sits in the epidermis and upper dermis, and scar walls sit deeper. So the first question is which problem matters more to you, and which is present.

Dr Sin Yong maps scar types with the skin stretched under directed light, and examines pigment with a dermatoscope where needed. He performs each treatment personally.

CO2 vs pico laser at a glance

Pico laserFractional CO2
Protocol hereT2 Frax Radiance on the DEKA TOROS3 Resurfacing Lift on the DEKA SmartXide Tetra Pro
Wavelength785 nm picosecond, with 532 nm and 1064 nm nanosecond10,600 nm
MechanismFragments pigment, mainly through pressureMakes ablative columns with intact skin between
TargetSun spots, freckles, some post-inflammatory marksBoxcar and rolling scar walls, surface texture
Surface afterwardsRedness and warmth, with treated spots crusting and sheddingRedness, swelling, oozing, crusting and peeling
Main limitDoes not rebuild a boxcar scar wallA poor way to remove a discrete sun spot
Main risk in Asian skinPost-inflammatory darkeningPost-inflammatory darkening

When a face needs both

A face with both problems may need both lasers, and the order depends on which problem dominates and on pigment risk. Where scarring dominates, CO2 usually goes first, and pico follows once the skin has healed. They are not stacked on the same area in one visit. Treating different zones on the same day is a separate decision. The plan may be staged further than seems necessary, and it may conclude that the second laser is not needed.

Spacing between the two

After CO2

Wait until the surface has closed, peeling has finished and pinkness is settling. Darkening can appear weeks later.

After pico

Resurfacing is planned only after the pinkness has gone and no late darkening has appeared.

At review

Spacing is set at review, with no fixed interval. A recent tan defers either laser.

Who should avoid combining them

Skin conditions

Active melasma over the field, active acne, infection or a cold sore in the area, and a keloid or hypertrophic scarring tendency.

Timing

A recent tan, photosensitising medicines, pregnancy, and recent isotretinoin until the interval has been discussed.

Healing

Conditions that slow healing.

Past darkening

A history of marked darkening after laser does not rule treatment out, but it changes settings and spacing.

Changing marks

These are examined first and may be referred.

What neither can do

Pico

It does not rebuild scar walls, release tethered scars or treat melasma's drivers, and it does not stop new pigment forming.

CO2

It does not remove a sun spot cleanly or treat pigment without a wound, and it does not return skin to an unmarked state.

Both together

A combination is not a promise of outcome.

Risks

Post-inflammatory hyperpigmentation can take months to fade. Prolonged redness, and pale or mottled spots after frequent toning, can also occur. While CO2 channels are open, infection, acne-like eruptions or cold sore flares are possible. Blistering or new scarring can follow if either laser is used too aggressively. These risks are reduced, not removed, by separate mapping, suitable settings, spacing and strict sun protection.

Fees

Fees depend on the area and zones, the assessment findings, the pico wavelengths and modes, the CO2 depth and density, whether subcision or TCA CROSS is included, and how the plan is staged. A written, itemised quote follows consultation. The second laser is quoted as a decision to be confirmed at review, not as part of a package. No prices are listed.

Frequently Asked Questions

CO2 addresses scar walls and texture. Pico addresses pigment and, in fractional mode, shallow texture. It does not rebuild a boxcar wall.
They are not stacked on the same area. Treating different zones on the same day is a separate decision.
It depends on which problem dominates and on pigment risk. Where scarring dominates, CO2 usually goes first.
There is no fixed interval. Spacing is set at review, once the skin has healed and late darkening has been ruled out.
It is a poor way to do so. Pico is used for discrete pigment.
No. The plan may conclude that the second laser is not needed.
SY
Dr Sin Yong
MBBS (NUS) · MRCS (Edinburgh)
MSc Aesthetic Medicine (QMUL) · MSc Practical Dermatology (Cardiff)
Aesthetic physician registered with the Singapore Medical Council.

Ask which comes first for you

Dr Sin Yong will examine you, explain your options and give any fee in writing.

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References

  1. Ptaszek B, et al. The Use of a Fractional Laser in Acne Scar Treatment-A Systematic Review. Life (Basel). 2025;15(6):915. View source · DOI · PMID 40566567
  2. Huang Y, et al. Successful Treatment of Freckles Using a 730-nm Picosecond Laser: A Prospective Study. Clin Cosmet Investig Dermatol. 2024;17:3027-3032. View source · DOI · PMID 39741582
  3. Harnchoowong S, et al. Cosmetic Considerations in Dark-Skinned Patients. Clin Cosmet Investig Dermatol. 2024;17:259-277. View source · DOI · PMID 38321987
  4. Liu Y, Zhang Z, Zhao J Minimally invasive interventions for atrophic acne scars: a PubMed/PMC-based systematic evidence review and exploratory network meta-analysis toward phenotype-guided interpretation. Front Surg. 2026;13:1943995. View source · DOI
  5. Liang S, et al. Comparison of the efficacy and safety of picosecond Nd:YAG laser (1,064 nm), picosecond alexandrite laser (755 nm) and 2% hydroquinone cream in the treatment of melasma: A randomized, controlled, assessor-blinded trial. Front Med (Lausanne). 2023;10:1132823. View source · DOI
  6. Puaratanaarunkon T, Asawanonda P A Randomized, Double Blinded, Split-Face Study of the Efficacy of Using a Broad Spectrum Sunscreen with Anti-Inflammatory Agent to Reduce Post Inflammatory Hyperpigmentation After Picosecond Laser. Clin Cosmet Investig Dermatol. 2022;15:331-337. View source · DOI

Studies may involve other devices or protocols, and they do not predict your own result. See our evidence library and editorial policy.

Related Treatments

Last updated 6 November 2026. General information only. Results vary between individuals. Images are illustrative and do not show patients.