What Profhilo is
Profhilo is an injectable bio-remodelling product made by IBSA. Each 2 mL syringe holds 32 mg of high-molecular-weight hyaluronic acid and 32 mg of low-molecular-weight hyaluronic acid, making 64 mg in total. The two are combined as a hybrid complex called NAHYCO. They are stabilised by heat and not chemically crosslinked.
This detail explains how the product behaves. Without crosslinking, it spreads through tissue and holds no shape. It is designed to act on skin quality, not on the contour of the face. That is why this page keeps returning to one point: Profhilo is not a dermal filler.
Results vary, so treat any published finding as background and not as a forecast.
How Profhilo differs from filler
| Profhilo | Dermal filler | |
|---|---|---|
| Structure | Not crosslinked, stabilised by heat | Crosslinked, so the gel holds a shape |
| In the tissue | Designed to spread | Holds a shape where it is placed |
| Purpose | Hydration and skin quality | Volume or projection |
| Good for | Crepey, dull or thin skin | A hollow cheek, a flat bridge or a receded chin |
| Shape change | None intended | The main aim |
| Concern it answers | Surface quality of the skin | Contour and structure |
| Next step if volume is the concern | Not the right tool | See dermal fillers or a collagen stimulator |
Bio Aesthetic Points
Profhilo is placed at a defined set of Bio Aesthetic Points, or BAP, on each side of the face. These points were chosen for vascular safety and for the way the product spreads. The modified BAP approach keeps those points as a safety framework and adds placement according to the shape of your face. Dr Sin Yong also treats scarred skin with it, which the standard protocol does not address. This means the number of areas can differ between people. Your plan is explained to you before treatment, including where the product will go and why. The BAP name matters less than the reasoning behind it. Placement is planned around anatomy and vessels first, then around the concern you have raised.
How many sessions?
No standard course number is given here. It would be misleading to state one before your skin has been seen. More than one visit may be advised, and any second placement is timed at review. The same applies to duration. Any specific figure you hear should be treated as an average across a study population, not a prediction for your skin. Hyaluronidase degrades hyaluronic acid, so the effect is not lifelong. Ageing also continues in the background. The honest position is that change is gradual, it is reviewed in person, and further treatment is a decision for that review.
Profhilo Singapore: who it suits
It tends to suit skin that is crepey, dull or thin, with poor hydration and fine surface lines. It is also used on the neck and the backs of the hands, and on scarred skin treated alongside the face. Jowls and a loose jawline are a different problem, and these are directed to focused ultrasound or radiofrequency. Hollows are directed to fillers or collagen stimulators, which are planned as a separate treatment. If the concern sits deeper in the outer face, Profhilo Structura may be discussed, although it is still not a conventional crosslinked filler. If your concern is the surface quality of the skin, Profhilo may be a reasonable fit. If your concern is shape, it is not. Many people arrive unsure which of these they have. A tired look can come from dull skin, from lost volume, from loose tissue, or from all three. Profhilo answers only the first, so a careful examination comes before any recommendation. You may also be advised on whether a related product fits better, and that is why the comparison further down this page is worth reading.
Who should avoid it or wait
A known allergy to hyaluronic acid or another component of the product. Tell the clinic about any reaction to earlier injections.
Pregnancy or breastfeeding, as it has not been studied in these groups. Active infection, inflammation, a cold sore or an acne flare at the injection sites.
Autoimmune disease, a history of severe allergy, a keloid tendency, a bleeding disorder or blood thinners.
What Profhilo cannot do
It cannot add projection or correct a hollow cheek, a flat bridge or a receded chin. It holds no shape, so there is nothing to build with.
It does not move descended tissue. Jowling and a loose jawline are directed to focused ultrasound or radiofrequency.
It is not an energy device. If loose skin is the concern, you may need Ultherapy or Thermage.
Pigment concerns, including melasma, need a different plan after assessment.
This is not a pore treatment. One small pilot measured a temporary change, which is not a result to expect.
It is a skin-quality treatment. It is not a substitute for a filler when volume has gone, or for an energy device when skin is loose.
Hyaluronic acid is degraded by hyaluronidase, so the effect is not lifelong.
Options that are often confused
| Option | Purpose | Placement | Limit |
|---|---|---|---|
| Profhilo | Skin quality and hydration | In the skin, from BAP points | No volume, lift or effect on pigment |
| Profhilo Structura | Change in the fat compartments of the outer face | Deeper, by cannula | Not a replacement for filler |
| HA skin boosters | Hydration of the dermis | Many small dermal injections | No volume or lift |
| Rejuran | Repair and texture | In the dermis | No volume or lift |
| Collagen stimulators such as Sculptra | Volume and firmness over time | Deeper planes | Not for surface hydration |
The visit and recovery
Risks and side effects
Small raised bumps at injection points, bruising, tenderness and short-lived swelling.
Lumps, infection and allergic reaction.
Contact the clinic if a bump does not settle, or if swelling, redness or pain gets worse. Allow the expected bumps to flatten on their own.
Vascular risks, linked to placement near facial vessels. This is the reason BAP placement is built around vascular safety, and why the injecting doctor needs to know the anatomy of the face. Sudden skin colour change or severe pain after any injection needs urgent assessment.
What affects the fee
No fee is published here. A written quote is given at consultation. It depends on the areas treated, the number of syringes, whether placement goes beyond the standard points, and whether Profhilo is combined with another treatment. The number of syringes is only clear once the areas have been agreed, so the quote comes after the examination, not before it.