PDLLA · Hyaluronic acid · Collagen stimulator

Juvelook Singapore

PDLLA microspheres carried in hyaluronic acid

Juvelook sits between a skin booster and a volumising filler. Any collagen response builds over months, and results vary from person to person.

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In Brief

Juvelook treatment in Singapore combines PDLLA microspheres with non-cross-linked hyaluronic acid. It suits skin-quality and fine-texture concerns, while Juvelook Volume addresses deeper contour. Any collagen response builds over months, and results vary. It cannot lift sagging skin, and it cannot be fully dissolved once placed.

At a Glance: Juvelook Singapore

What it isPDLLA microspheres combined with non-cross-linked hyaluronic acid.
Device or productJuvelook and Juvelook Volume, made by VAIM Co., Ltd. in Korea.
Used forSkin quality and fine texture; Juvelook Volume addresses deeper contour.
Not suited toKnown allergy to a component, or a tendency to keloids or raised scarring.
What it cannot doJuvelook cannot lift sagging skin or be fully dissolved once placed.
Main risksSwelling, bruising, tenderness and small bumps; nodules can occur with any collagen stimulator.

What the Research Shows: Juvelook Singapore

  • A 2026 randomised assessor-blinded trial of 448 adults reported greater skin hydration with non-cross-linked hyaluronic acid than no treatment at all post-treatment points (P<0.001), with no serious adverse events. [2]
  • A 2024 systematic review of 11 trials reported mild-to-moderate events including nodules; five trials had high risk of bias and authors rated the evidence low quality. [3]
  • A 2026 Chinese double-blind randomized trial of 252 adults compared PLLA microspheres, not Juvelook, with hyaluronic acid for nasolabial folds; erythema occurred in 93.7% with PLLA versus 80.8% with HA. [4]

Figures describe published study groups, which may have used other devices or protocols. They do not predict your result. Updated 7 November 2026.

About This Treatment

What is Juvelook?

Juvelook is made by VAIM Co., Ltd. in Korea. The manufacturer classes it as a disposable medical device for temporary improvement of facial wrinkles in adults. It contains poly-D,L-lactic acid, or PDLLA, in non-cross-linked hyaluronic acid. The powder is reconstituted before injection.

The first question is whether your concern is skin quality, volume or laxity. Juvelook targets the first two. It is not a lifting treatment. Dr Sin Yong makes this assessment himself, and he also sees patients who had Juvelook placed elsewhere.

What is the difference between Juvelook and Juvelook Volume?

Juvelook, 50 mg vial

Contains 42.5 mg PDLLA and 7.5 mg hyaluronic acid. Used for skin quality, fine lines and texture.

Juvelook Volume, 200 mg vial

Contains 170 mg PDLLA and 30 mg hyaluronic acid, and is sold internationally as Lenisna. Used for deeper volume and contour.

How does Juvelook treatment in Singapore work?

The hyaluronic acid targets hydration on the day. The PDLLA then aims to prompt your skin to build its own collagen over the following months. The particles are spherical, partly porous and amorphous. Sculptra particles are different: sheet-like and semi-crystalline. Juvelook uses hyaluronic acid as its carrier, while Sculptra uses carboxymethylcellulose. This is why it is described as a collagen stimulator, and why the change arrives slowly.

How is Juvelook different from a skin booster or Rejuran?

All three are injected into the skin, but they do different jobs. Juvelook sits between a skin booster and a filler, and the clearest difference is what stays behind in the tissue. The skin booster guide and the Rejuran page cover the other two.

FeatureJuvelookHydrating boosterPolynucleotide (Rejuran)
MaterialMicrospheres of PDLLA, carried in hyaluronic acidHyaluronic acid, free or lightly bondedPurified DNA chains from salmon
AimA gradual collagen response around the microspheresHydration where it is placedA repair signal to the dermis
Particles left behindYes, microspheresNoNo
HyaluronidaseActs on the carrier only, not the PDLLAActs on itDoes not act on polynucleotide
Key allergy checkAny componentHyaluronic acid or lidocaineFish or salmon

Who is Juvelook suitable for?

Skin quality

Concerns about skin quality or fine texture.

Volume

Volume concerns where structure is the aim, using Juvelook Volume.

Sagging skin

If sagging is your main concern, Juvelook is the wrong tool. The consultation will separate this from a skin-quality or volume concern.

Which concerns and areas is Juvelook considered for?

No fixed list of areas is published, because placement and dilution are set after examination. What the examination finds steers the choice, and Juvelook is often not the answer.

What the examination findsJuvelook?What is weighed instead or alongside
Fine lines, crepey or thin skin, fine textureOften consideredEnergy-based treatment for the skin, which adds no product
Deeper volume or contourJuvelook Volume may be consideredFiller for a defined hollow, or Sculptra for gradual volume
A hollow under the eyesPossible, with careThe Restore arm of the VF Lift, often preferred there
Sagging along the jaw or cheeksNoA lifting treatment
A heavy face from layered injectablesNoUltrasound mapping first, then correction
Dull, dehydrated skinSometimesA hyaluronic acid booster or Profhilo
Acne scarsDecided at examinationA plan by scar type; see acne scar treatment

What has been studied

PDLLA has been studied in the nasolabial folds and the tear trough. Published follow-up is short, so this work cannot predict your result. Juvelook can be used under the eyes, yet the clinic prefers energy-based care there: FSX Laser for skin, and the Restore arm of the VF Lift for hollow areas.

What did the PDLLA studies report?

The published work is small and early. A 2026 prospective case series treated the nasolabial folds of 20 patients with Juvelook, in three sessions a month apart, and assessed them three months after the last session. [6] It reported 85% rated improved or much improved on a global aesthetic scale, with only transient swelling and bruising, and no nodules or granulomas in that time. There was no comparison group.

A 2025 paper on Korean women with tear trough deformity, also using Juvelook, followed patients to six months and reported improvement on the Hirmand classification without severe complications. [7] Its abstract gives no patient numbers and describes no control group, and the authors call for comparative studies.

A 2024 literature review of PDLLA in dermatology highlights granulomas and non-inflammatory nodules as possible complications. [8] None of this work compared Juvelook with Sculptra or with hyaluronic acid filler, and all three papers share an author. It cannot predict your own result, and results vary.

Who should avoid it or wait

Wait

Pregnancy or breastfeeding, and active infection or inflammation in the area, including an acne flare or cold sore.

Avoid

Known allergy to a component, or a tendency to keloids or raised scarring.

Assessed first

Earlier filler or collagen stimulator of unknown type, with ultrasound where needed.

Poor fit

Sagging as the main concern, or wanting a fully reversible result.

What Juvelook cannot do

Lift sagging

Laxity is a lifting problem and needs a different approach.

Fully dissolve

Hyaluronidase breaks down the hyaluronic acid carrier, but not the PDLLA.

Match Sculptra on proof

No randomised trial comparing them has been published.

Promise a duration

No duration is promised, and published follow-up is short.

How Dr Sin Yong approaches Juvelook

Dr Sin Yong examines you and does every injection himself. The first thing he settles is which of three problems you have: skin quality, lost volume or laxity.

What he checks

What has been injected before, as far as you know it. Where earlier filler is involved he scans it with ultrasound first, and he performs the scan himself.

What he weighs

He compares Juvelook with the energy-based treatments he favours, which leave no product behind, and tells you plainly when an injectable is the right tool for the job. Placement and dilution are then fixed and written into your plan.

What he declines

Juvelook is not used when sagging is the main concern, because that is a lifting problem. He does not inject more product over a lump; further filler or collagen stimulation waits until the lump has been dealt with.

What he postpones

Treatment waits through infection or inflammation in the area, such as an acne flare or a cold sore. Earlier filler or collagen stimulator of unknown type is assessed before anything new is added. Excess Juvelook placed elsewhere is corrected rather than added to.

“Juvelook is a skin-quality tool first. If the real problem is sagging, more product is the wrong answer.”

Dr Sin Yong

What happens during a Juvelook treatment?

The visit starts with an examination, not an injection.

01
Examination
Dr Sin Yong decides whether the concern is skin quality, volume or laxity, and asks what has been injected before. Earlier filler is scanned with ultrasound.
02
A written plan
The product, areas, placement and dilution are set and given to you in writing. You do not have to decide on the day.
03
Preparing the product
Juvelook comes as a powder and is mixed with liquid before injection.
04
Numbing
A numbing cream may go on first. Expect small pricks with some sting or pressure, more so under the eyes, and say if you need a pause.
05
Injection
Dr Sin Yong places the product himself, area by area, as planned.
06
Straight after
Small raised bumps, swelling and redness are expected. You leave with written aftercare, including whether to massage at all.
07
Review
The area is reviewed once the swelling has gone, and any further placement is decided then.

What should I expect in the days after Juvelook?

The early fullness and bumps are not the result: much of it is the mixing liquid and swelling. Massage follows only the instruction given at your visit, and some areas, such as under the eyes, are not massaged at all.

PhaseWhat is usualWhat to doWhat to avoid
Straight afterA raised bump at each point; redness, swelling, tenderness; sometimes a bruiseCool compress for short spells; sleep with your head slightly raisedMake-up over the points, rubbing, saunas, alcohol and hard exercise
The early phaseBumps flatten; swelling eases steadily rather than growingMassage only as shown; daily sunscreen; make-up once the points have closedFacials, gua sha, face massage or home devices on the area
In the months afterThe area feels ordinary; any collagen response builds slowly and variesA simple routine; photograph any small lump you notice and send itAny other injectable in the area before your review

What are the side effects of Juvelook?

Swelling, bruising, tenderness and small bumps at injection points are expected and settle. Nodules can occur with any collagen stimulator. One case report described non-inflammatory tear-trough nodules after PDLLA. The serious risk is vascular occlusion, where product enters a blood vessel. The clinic also sees patients who had Juvelook placed elsewhere. If you have had any earlier filler or collagen stimulator, please say so, as it is assessed first.

What is a lump after Juvelook, and how is it assessed?

Every lasting lump is scanned before anything is decided, because lumps of different make-up can feel alike. Ultrasound shows where the material sits, how deep it is and whether other fillers share the area. The rows below run from expected to urgent.

What you noticeWhat it may beFirst step
Small bumps at the injection pointsExpected: product and swelling settlingFollow your aftercare
A firm lump that is not red or tenderOften microspheres gathered in one place, or placed too near the surfaceUltrasound mapping, then a plan
A lump that appears later or keeps growingA nodule or, rarely, a granulomaHave it scanned
Fever, spreading redness, pus, or a red hot lumpPossible infection or inflammationA doctor the same day, or A&E if none can see you
Skin turning white, grey or mottled, or pain that is getting worsePossible blocked blood vesselUrgent assessment by the injector or A&E now
Change in vision or eye painEmergencyCall 995
Trouble breathing or swallowing, or swelling of the tongue or throatEmergencyCall 995

If a nodule appears

Juvelook contains PDLLA with hyaluronic acid, so hyaluronidase can act only on the hyaluronic acid part. A firm nodule needs examining before anyone treats it. Dr Sin Yong maps it with ultrasound, treats any inflammation medically first, and may then use the Sculpting mode of Time Freeze Laser LCLR® on firm excess, without an incision. The published record is small. One case report describes PDLLA nodules in one woman treated with monopolar radiofrequency, with no control or biopsy. [5] That is a different device, and we found no published study of long-pulsed 1064 nm laser on PDLLA nodules, so this use rests on Dr Sin Yong's clinical experience. Laser heat has its own risks. See Ellansé and Sculptra lumps.

Warning signs after injection

Vision change or eye pain

Call 995 now.

Pale, dusky or mottled skin, or worsening pain

You need urgent assessment by the injecting doctor or at A&E.

A red, hot or painful lump

See a doctor the same day, or go to A&E if none is available.

How is Juvelook regulated in Singapore?

VAIM, the Korean maker, describes it as a single-use device intended to temporarily improve facial wrinkles in adults. In Singapore, medical devices, injectable fillers among them, come under the Health Sciences Authority.

Before any injectable, it is reasonable to ask for the exact product name and to search the HSA register yourself. At this clinic, Dr Sin Yong examines you and performs the injections himself. The guide to aesthetic medicine regulation in Singapore explains who oversees doctors, products and clinics.

What should I ask before Juvelook?

The PDLLA in Juvelook cannot be dissolved, so these questions are worth asking before treatment, here or anywhere.

About the plan

Will the doctor who examines me also do the injecting? Which product is planned, Juvelook or Juvelook Volume, and why not a booster or Sculptra?

About the limits

Is any part of my concern sagging, which this cannot address? If I change my mind later, what can and cannot be undone?

About safety

How often do nodules happen, and how would one be checked? Who do I contact after treatment, and what aftercare comes with it?

About alternatives

Was energy-based treatment considered for me, and is no injection a reasonable choice?

How much does Juvelook cost in Singapore?

Fees are not published, and any fee is given in writing after examination. They depend on whether the concern is skin quality or volume, the areas treated, dilution and placement, and any earlier filler needing attention first. Session numbers are not published either: placement, dilution and the number of sessions are set after examination. A written plan with fee factors follows your consultation. Please ask about aftercare at that visit, so that you know what to expect.

Frequently Asked Questions

Juvelook is used for skin quality, fine lines and texture. Juvelook Volume is used for deeper volume and contour. Results vary.
It sits between the two. The hyaluronic acid targets hydration on the day, and the PDLLA aims to prompt collagen over the following months.
It uses PDLLA in hyaluronic acid, while Sculptra uses PLLA in carboxymethylcellulose. The particles also differ. No randomised trial has compared them.
Any collagen response builds over months, and results vary.
No duration is promised. Published follow-up is short, so a firm figure cannot be given.
Only in part. Hyaluronidase breaks down the hyaluronic acid carrier but not the PDLLA.
No. Sagging is a lifting problem, and your plan would need a different approach.
This is decided after examination, along with placement and dilution. Session counts are not published.
It can, and PDLLA has been studied in the tear trough. The clinic prefers energy-based treatment in this area, and a case report describes nodules there.
The PDLLA in Juvelook cannot be dissolved. Hyaluronidase acts on the hyaluronic acid in Juvelook, not on the PDLLA. Nodules are mapped with ultrasound, inflamed ones are treated medically first, and firm excess may be treated with the Sculpting mode of Time Freeze Laser LCLR®. We found no published study of this use.
The fee is given in writing after Dr Sin Yong has examined you, because the plan has to come first. It depends on whether the concern is skin quality or volume, which product fits, the areas, dilution and placement, and whether earlier filler needs attention first. A figure before examination would price a product, not your plan.
Expect a run of small needle pricks, with some sting or pressure as each deposit goes in. The feeling varies with the area, the depth and the person, and the under-eye area is usually the most sensitive. Numbing cream can go on beforehand, and Dr Sin Yong checks how you are as he works.
Small bumps at the injection points, swelling, redness, tenderness and bruising are expected and settle. Nodules can occur with any collagen stimulator, sometimes weeks or months later, and a lump that lasts is scanned. As with any injection into the face, the serious risk is a blocked blood vessel, which needs urgent care.
Every facial injection carries some risk. Most effects are short-lived bruising, swelling and bumps; the serious ones are infection and, rarely, a blood vessel being blocked. Studies of Juvelook itself are few and small, so Dr Sin Yong goes through the risks, nodules included, before any plan is agreed.
No fixed time can be given, because it varies with the area, the version used and your skin. The small bumps at each injection point flatten as the swelling settles. A bump that grows, hardens, turns red or stays once the rest has settled is not part of that, and should be reported.
Only when Dr Sin Yong has asked you to, and only in the way he showed you. Sculptra is known for a fixed massage routine; Juvelook is not handled the same way, and some areas, the under-eye included, get no massage. A bump that is red, warm or sore should never be kneaded.
At first, avoid make-up over the injection points, saunas, steam, alcohol and hard exercise. Facials, facial massage, gua sha and at-home devices wait, and no other injectable should go into the area before your review. Use sunscreen daily, keep any bruise out of the sun, and report a lump that grows or hurts.
They are close relatives, not the same. Each is a lactic acid polymer used to prompt collagen. Juvelook's PDLLA has an unordered structure and rounded particles, carried in hyaluronic acid; Sculptra's PLLA is partly ordered, with flat, sheet-like particles. Neither polymer breaks down with hyaluronidase.
Treatment is put off in pregnancy, while breastfeeding, and while the skin in the area is infected or inflamed, for example by acne or a cold sore. A known allergy to an ingredient, or a tendency to keloids or raised scarring, means it is avoided. It is also a poor match for sagging, or for anyone wanting a fully reversible result.
Often, but the earlier product is assessed first. If you do not know what was used, Dr Sin Yong scans the area with ultrasound before adding anything, since years of layered fillers and stimulators commonly make a face look heavy. Any excess he finds is corrected before new product is considered.
Not as a scar treatment in its own right. Fine texture is among its uses, but acne scars are planned by scar type: tethered scars are released by subcision, and fixed-wall scars are resurfaced. Whether any collagen stimulator has a place in your scar plan is decided at examination with Dr Sin Yong.
The material. Juvelook places PDLLA microspheres in a hyaluronic acid carrier, intended to prompt a gradual collagen response. Rejuran places polynucleotide purified from salmon DNA, with no particles, and is directed at how the skin repairs itself. Neither suits everyone, and the examination decides which, if either, fits.
SY
Dr Sin Yong
MBBS (NUS) · MRCS (Edinburgh)
MSc Aesthetic Medicine (QMUL) · MSc Practical Dermatology (Cardiff)
Doctor registered with the Singapore Medical Council.

Juvelook Consultation

Dr Sin Yong will examine you, explain your options and give any fee in writing.

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References

  1. Ghatge AS, Ghatge SB The Effectiveness of Injectable Hyaluronic Acid in the Improvement of the Facial Skin Quality: A Systematic Review. Clin Cosmet Investig Dermatol. 2023;16:891-899. View source · DOI
  2. Cheng H, et al. A Prospective, Multicenter, Randomized, Assessor-Blinded Study Assessing the Efficacy and Safety of Injectable Non-Cross-Linked Hyaluronic Acid for Improving Facial Skin Rejuvenation. Clin Cosmet Investig Dermatol. 2026;19:1-10 (article 590699). View source · DOI
  3. Signori R, Barbosa AP, Cezar-dos-Santos F, Carbone AC, Ventura S, Nobre BBS, Neves MLBB, Câmara-Souza MB, Poluha RL, De la Torre Canales G Efficacy and Safety of Poly-l-Lactic Acid in Facial Aesthetics: A Systematic Review. Polymers (Basel). 2024;16(18):2564. View source · DOI · PMID 39339028
  4. Wang Z, Ting W, Zhao H, Huang L, Ma J, Liu H, Liang Y, Shu M, Jin L, Yu N, Long X Long-Term Correction of Nasolabial Folds Using Poly-L-Lactic Acid Microspheres: A Multicenter, Double-Blinded, Randomized Trial. Aesthet Surg J Open Forum. 2026;8:ojag001. View source · DOI · PMID 41694326
  5. Seo SB, Wan J, Yi KH. Energy-Based Device Management of Nodular Reaction Following Poly-D, L-Lactic Acid Injection for Tear Trough Rejuvenation. J Cosmet Dermatol. 2025;24(1):e16575. View source · DOI · PMID 39283001
  6. Yi KH, Rosellini I, Min JLJ, Kim HS. A Clinical Study on the Efficacy and Safety of Injectable PDLLA for Nasolabial Fold Correction: Juvelook treatment for Nasolabial fold. J Craniofac Surg. 2026;Published ahead of print (July 2026); volume and pages not yet in the record. View source · DOI · PMID 42479568
  7. Wan J, Hidajat IJ, Cartier H, Garson S, Bautzer C, Machado LB, Leite P, Yi KH. Evaluating Poly-D,L-Lactic Acid for Lower Eyelid Rejuvenation: Efficacy and Safety. J Cosmet Dermatol. 2025;24(3):e70058. View source · DOI · PMID 40017393
  8. Lee KWA, Chan LKW, Lee AWK, Lee CH, Wong STH, Yi KH. Poly-d,l-lactic Acid (PDLLA) Application in Dermatology: A Literature Review. Polymers (Basel). 2024;16(18):2583. View source · DOI · PMID 39339047

Studies may involve other devices or protocols, and they do not predict your own result. See our evidence library and editorial policy.

Related Treatments

Last updated 7 November 2026. General information only. Results vary between individuals. Images are illustrative and do not show patients.