Fillers · Biostimulators · Comparison

Radiesse vs Ellanse vs HA Fillers

The main difference is how each one works

HA fillers add adjustable volume. Radiesse and Ellanse act as collagen stimulators, so change is gradual, and they cannot be dissolved. Results vary.

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In Brief

Radiesse vs Ellanse vs HA fillers is a choice between adjustable volume and gradual collagen stimulation. HA suits precise shaping and first-time patients. Radiesse and Ellanse suit structural areas such as the jawline. Neither can be dissolved, and none of them tightens skin. Results vary.

At a Glance: Radiesse vs Ellanse vs HA Fillers

What it comparesHA filler, Radiesse (CaHA) and Ellanse (PCL).
Main differenceHA gives adjustable volume; Radiesse and Ellanse rely on gradual collagen stimulation.
Can it be dissolved?HA can, with hyaluronidase; Radiesse and Ellanse cannot.
Used forHA for precise shaping; Radiesse and Ellanse for structural areas such as the jawline.
What it cannot doNone of the three lifts sagging tissue or tightens skin.
Main risksSwelling, bruising, nodules, granulomas and, uncommonly, vascular occlusion.

What the Research Shows: Radiesse vs Ellanse vs HA Fillers

  • A 2023 manufacturer-funded systematic review of 12 studies reported increased collagen and cell proliferation with calcium hydroxylapatite, but most studies had methodological limitations and only 7 had a control group. [1]
  • A 2015 expert consensus on filler-related impending necrosis, not a trial, recommended at least 200 U of hyaluronidase, more if no improvement within 60 minutes, and said early treatment within 24 hours usually gave better outcomes. [2]
  • A 2021 manufacturer-funded consensus of 12 Asian experts agreed cannulas should be used for calcium hydroxylapatite but disagreed on several points, citing diverse patient presentations. [5]

Figures describe published study groups, which may have used other devices or protocols. They do not predict your result. Updated 6 November 2026.

About This Topic

Two different ideas

HA filler is a gel that gives volume on the day. It can be adjusted, and it can be dissolved with hyaluronidase. Radiesse and Ellanse are different. They contain tiny particles in a gel carrier. As the particles slowly break down, your own fibroblasts build new type I collagen around them.

So the choice is not about which product is stronger. It is about the job. A material that suits the lips may be the wrong one for the jawline, and the reverse also applies.

Radiesse vs Ellanse vs HA fillers at a glance

HA fillerRadiesse (CaHA)Ellanse (PCL)
How it worksGel adds volumeMicrospheres support and stimulate collagenMicrospheres stimulate collagen and break down slowly
On the dayAdjustable volumeFirm support where placedSome support
Typical areasLips, tear troughs, precise shapingJawline, hands, diluted for skin qualityJawline, chin, backs of the hands
Can it be dissolved?Yes, with hyaluronidaseNoNo
Change over timeNot reliant on collagen responseGradual and structuralGradual and structural
Read moreDermal filler guideRadiesseEllanse

When each one may suit

HA filler

Lips, tear troughs, fine shaping and first-time patients who want something adjustable.

Radiesse

Firm support at the jawline or hands, where the plan accepts a change that cannot be undone.

Ellanse

Gradual support at the jawline, chin or backs of the hands.

Other collagen stimulators

Sculptra (PLLA) gives little volume on the day and is used for diffuse mid-face loss. See Sculptra vs Radiesse.

What these products cannot do

None of the three lifts sagging tissue or tightens skin. Volume placed under tissue that has moved down does not raise it. Radiesse and Ellanse cannot shape lips, and they will not give a quick change for an event. Because they cannot be dissolved, excess or misplaced product has to be managed, not erased. Dosing is therefore conservative and staged. The approach is to under-treat, wait and reassess. No duration can be promised for any product. Longevity depends on the material, amount, plane, your collagen response, metabolism, facial movement and ageing.

How treatment is planned

01
Assessment
Your doctor looks at your face at rest and in movement, separating volume loss from descent. Earlier filler is mapped with ultrasound.
02
Written plan
This names the product, regions, dilution, plane, the amount used now and the amount held back, along with a quote.
03
Injection
After topical anaesthetic, small deep volumes are placed region by region with a fine needle. A cannula may be used.
04
Review and care
Review is timed to the collagen response, not to swelling. Avoid pressing the area, heat, alcohol and strenuous exercise as advised. Do not massage Ellanse unless told to.

Who should wait or avoid them

Wait

Pregnancy or breastfeeding, infection or inflammation in the area such as an acne flare or cold sore, or an event coming up soon.

Assess first

Earlier filler or an unknown product, which is mapped with ultrasound. Bleeding disorders or blood thinners, active autoimmune conditions, and a keloid or granuloma history.

Avoid

A known allergy to any component. Collagen stimulators are also a poor fit for lips, tear troughs and fine lines.

Risks to know about

Swelling, bruising, tenderness and small bumps at injection points are expected early on. Less common problems are lumps or nodules, sometimes delayed, as well as asymmetry, overcorrection and granulomas. Vascular occlusion is uncommon but time-critical. Seek urgent help for blanched, dusky or mottled skin or worsening pain. Any change in vision or eye pain needs a 995 call. Read about vascular occlusion warning signs. A firm lump with no redness needs a planned review. Results vary.

Frequently Asked Questions

Only HA filler can be dissolved, using hyaluronidase. Radiesse and Ellanse cannot, so excess product is managed, not erased.
HA filler is generally preferred, because it is adjustable and can be dissolved if needed.
No. They add support and stimulate collagen, but they do not lift descended tissue or tighten skin.
No duration can be promised. It depends on the product, amount, plane, collagen response, metabolism and movement.
They are not claimable under MediSave or MediShield Life, and most private insurance excludes them. A written quote follows assessment.
SY
Dr Sin Yong
MBBS (NUS) · MRCS (Edinburgh)
MSc Aesthetic Medicine (QMUL) · MSc Practical Dermatology (Cardiff)
Aesthetic physician registered with the Singapore Medical Council.

Ask which material fits the area

Dr Sin Yong will examine you, explain your options and give any fee in writing.

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References

  1. Amiri M, et al. Skin regeneration-related mechanisms of Calcium Hydroxylapatite (CaHA): a systematic review. Front Med (Lausanne). 2023;10:1195934. View source · DOI
  2. Cohen JL, et al. Treatment of Hyaluronic Acid Filler-Induced Impending Necrosis With Hyaluronidase: Consensus Recommendations. Aesthet Surg J. 2015;35(7):844-849. View source · DOI · PMID 25964629
  3. Aguilera SB, et al. The Role of Calcium Hydroxylapatite (Radiesse) as a Regenerative Aesthetic Treatment: A Narrative Review. Aesthet Surg J. 2023;43(10):1063-1090. View source · DOI · PMID 37635437
  4. Goodman GJ, et al. A Consensus on Minimizing the Risk of Hyaluronic Acid Embolic Visual Loss and Suggestions for Immediate Bedside Management. Aesthet Surg J. 2020;40(9):1009-1021. View source · DOI · PMID 31693068
  5. Corduff N, et al. Pan-Asian Consensus on Calcium Hydroxyapatite for Skin Biostimulation, Contouring, and Combination Treatments. J Clin Aesthet Dermatol. 2021;14(8):E76-E85. View source · PMID 34840663
  6. Hong GW, et al. Adverse Effects Associated with Dermal Filler Treatments: Part II Vascular Complication. Diagnostics (Basel). 2024;14(14):1555. View source · DOI · PMID 39061692

Studies may involve other devices or protocols, and they do not predict your own result. See our evidence library and editorial policy.

Related Treatments

Last updated 6 November 2026. General information only. Results vary between individuals.