Calcium hydroxylapatite · 微晶瓷 · Not dissolvable

Radiesse Singapore: calcium hydroxylapatite for structure or skin quality

One product, two very different uses.

Radiesse can be placed deep for support, or diluted and placed shallow for firmness and texture. Either way, hyaluronidase cannot dissolve it.

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In Brief

Patients in Singapore ask about Radiesse, a calcium hydroxylapatite injectable used deep for structure or diluted for skin quality. It may suit firm areas such as the chin, or crepey skin, in people who accept it cannot be reversed. It does not lift a descended jowl.

At a Glance: Radiesse Singapore

What it isA calcium hydroxylapatite (CaHA) injectable, used deep for structure or diluted for skin quality.
Device or productRadiesse by Merz; Radiesse (+) has lidocaine added.
Used forFirm areas such as the chin, or crepey skin, accepting it cannot be reversed.
Not suited toAnaphylaxis history, several severe allergies, CaHA allergy or bleeding disorders.
What it cannot doRadiesse cannot be dissolved by hyaluronidase and does not lift a descended jowl.
Main risksSwelling, bruising and tenderness; nodules or product you can see or feel.

What the Research Shows: Radiesse Singapore

  • A 2023 manufacturer-funded systematic review of 12 studies reported increased collagen and cell proliferation with calcium hydroxylapatite, but most studies had methodological limitations and only 7 had a control group. [1]

Figures describe published study groups, which may have used other devices or protocols. They do not predict your result. Updated 6 November 2026.

About This Treatment

Gel first, collagen after

Radiesse is made by Merz. It is calcium hydroxylapatite, or CaHA, in the form of microspheres of 25 to 45 µm. These make up about 30% of the syringe, in about 70% gel carrier. Radiesse (+) has lidocaine added. In Chinese it is known as 微晶瓷.

The gel gives some volume on the day. In the following weeks, fibroblasts lay down collagen around the microspheres, and any later change depends on that collagen once the gel has been absorbed. The body metabolises the microspheres gradually into calcium and phosphate, so the change does not last for life. Results vary.

Two ways Radiesse treatment is used in Singapore

Undiluted or lightly diluted

A structural use. Small amounts go deep at the chin, jawline, pre-jowl area and backs of the hands.

Hyperdiluted

Mixed with saline and lidocaine and placed shallow, often by cannula. It is used for firmness and texture on the neck, chest, arms, abdomen, thighs, buttocks and hands. It adds almost no volume, and change comes gradually.

Acne scars

Diluted Radiesse can be placed under a rolling scar after subcision, aiming to keep the released space open while collagen forms. It is not used for ice-pick or boxcar scars.

Who it may suit

It may suit you if you need structural support in firm tissue, such as the chin, jawline, outer cheek or hands. Diluted use may suit crepey or loose skin on the neck, chest, arms, abdomen and hands, if you accept that change is slow and that this is not a volume treatment. In both cases you need to be comfortable that it cannot be reversed. If you have never been assessed, a reversible hyaluronic acid filler is a more forgiving place to start.

Who should avoid it or wait

Avoid

A history of anaphylaxis or several severe allergies. Known allergy to CaHA, its components or, for Radiesse (+), lidocaine. Bleeding disorders.

Postpone

Pregnancy or breastfeeding, as safety has not been established. Infection or inflammation at the site, including active acne or a cold sore.

Needs a different plan

Autoimmune disease or immunosuppressive treatment. Keloid or hypertrophic scarring, considered case by case. Blood thinners, which mean more bruising. Recent or planned dental work.

Not over other filler

It is not injected over non-absorbable filler such as silicone. Filler of unknown type is scanned first.

What Radiesse cannot do

Hyaluronidase acts only on hyaluronic acid, so it will not dissolve Radiesse. A misplaced result has to be managed. Radiesse does not lift a descended jowl or loose jawline, and volume placed below a jowl can make it look heavier. For laxity the doctor may discuss focused ultrasound or the 4K Body Lift. It is not used in lips, tear troughs or the glabella, where a reversible hyaluronic acid product is chosen. Diluted use adds no real volume. It does not treat hanging skin, pigment or veins on the hands.

Scans, and what to tell us first

Radiesse is radio-opaque. It can be seen on X-ray, CT and ultrasound. Tell your radiologist and dentist that you have had it. Before your visit, declare all earlier fillers, pregnancy, breastfeeding, autoimmune conditions, keloid history and blood thinners. Avoid fresh sun exposure, and pause strong skincare actives as advised.

Side effects and risks

Expected

Swelling, bruising, tenderness, and short-lived firmness where undiluted product sits.

Product-related

Nodules, or product you can see or feel, from shallow placement. Diluted use in thin skin can leave unevenness or small nodules.

Serious

Vascular problems, as with any injectable near facial vessels. Depth and anatomy matter most.

When to act

Red, hot, painful or swollen lump: see a doctor the same day, or A&E if none is available. Pale, dusky or mottled skin, or worsening pain: get urgent assessment now from your injecting doctor or A&E. Change in vision or eye pain: call 995 now. More in our warning signs guide.

Lumps and corrections

Lumps and heaviness after earlier filler are assessed before any plan is made, and adding more is rarely the first step. Ultrasound mapping comes before any laser treatment. Firm nodules may be treated without surgery, including with the Sculpting mode of Time Freeze Laser LCLR®, though we found no published study of this use. Inflamed lumps are treated medically first, and laser heat has its own risks. See Ellansé and Sculptra lumps. A medical injection that can degrade CaHA nodules has also been reported. It is a management option, not routine care and not a true reversal. See our page on pillow face for more on excess filler.

Recovery, in phases

01
Straight after
Swelling, tenderness and short-lived firmness, with some volume visible.
02
That evening
Avoid pressure, heat, hard exercise and alcohol. Sleep face-up.
03
Next few days
Swelling and bruising settle and firmness softens. Make-up can cover bruising once entry points have closed.
04
Over months
Any collagen response develops over this period.
05
Follow-up
Any lump, asymmetry or heaviness is examined, with ultrasound where useful.

How long it lasts, and how fees work

No duration is promised. It depends on dilution, area, amount, your tissue and any weight change. Review timing is set at consultation. Fees are not published. They depend on undiluted or diluted use, the areas, the amount and dilution needed, staging, and any combined treatment. A written quote comes at consultation, along with a plan that includes the option of no treatment.

Frequently Asked Questions

Both, one after the other. The gel adds volume, and collagen is then meant to form around the microspheres.
Not with hyaluronidase. A medical injection option exists for nodules, but it is a way of managing them, not a true reversal.
Not always. Lumps are mapped and can be treated without an incision, including with the Sculpting mode of Time Freeze Laser LCLR. Surgery leaves a scar and carries a risk of dents or nerve injury.
Radiesse adds some volume on the day and aims to prompt collagen. Sculptra adds almost no immediate volume. See Sculptra vs Radiesse.
No. Those areas call for a reversible hyaluronic acid product.
Yes. It is the Chinese name for the same product.
This varies. Swelling and bruising are possible, and hard exercise and pressure are avoided at first.
Possibly, with hyaluronic acid filler, botulinum toxin, or skin treatments such as FSX Laser. This is decided at assessment.
It depends on dilution, areas, amount, staging and any combined treatment. You receive a written quote at consultation.
SY
Dr Sin Yong
MBBS (NUS) · MRCS (Edinburgh)
MSc Aesthetic Medicine (QMUL) · MSc Practical Dermatology (Cardiff)
Doctor registered with the Singapore Medical Council.

Ask whether Radiesse suits your concern

Dr Sin Yong will examine you, explain your options and give any fee in writing.

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References

  1. Amiri M, et al. Skin regeneration-related mechanisms of Calcium Hydroxylapatite (CaHA): a systematic review. Front Med (Lausanne). 2023;10:1195934. View source · DOI
  2. Aguilera SB, et al. The Role of Calcium Hydroxylapatite (Radiesse) as a Regenerative Aesthetic Treatment: A Narrative Review. Aesthet Surg J. 2023;43(10):1063-1090. View source · DOI · PMID 37635437

Studies may involve other devices or protocols, and they do not predict your own result. See our evidence library and editorial policy.

Related Treatments

Last updated 6 November 2026. General information only. Results vary between individuals. Images are illustrative and do not show patients.